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OCR: totroph In some patients with acromegaly, som hyperplasia may occur because of excess secretion of GHRH from a hypothalam ly present hamartoma (a tumour-like lesion, usu ral body at birth, which ceases to grow when ger oma (a growth ceases), hypothalamic gangliocy hoid tumour of mature gangliocytes), or care r, over tumour of the lung or pancreas, Hower rimary ninety-nine per cent of patients have a y a role in pituitary tumour, Genetic factors may p crine some tumours, such as in multiple end neoplasia (MEN) syndrome type 1, whe ne of the GH-secreting adenomas may constitute neoplastic components,